Background: It is important to understand the specific HPV genotype distribution in screen-detected lesions. HPV\nGenotype is helpful for separating HPV-positive women at greater risk of cancer from those who can regress\nspontaneously and for preventing cervical cancer at early stage. The aim of this study was to investigate the\nhigh-risk HPV genotype distribution among cervical cytology abnormality in Pearl River Delta Region, Southern China\nMethods: 5585 HPV-infected women were screened from 77069 women in Pearl River Delta Region. Information was\nobtained from 3226 screened subjects through questionnaires and personal interviews. Exfoliated cervical cells were\ncollected by doctors for HPV test with MassARRAY (Sequenom, Sandiego, CA) technique based on the matrix-assisted\nlaser desorption/ionization time-of flight (MALDI-TOF) mass spectrometry (MS). The ThinPrep cytology test was performed\nto screen for cervical cancer. Unconditional logistic was used to determine the most common HPV carcinogenic types.\nResults: Of the 3226 HPV-positive samples tested, 1744 (54.1%) with normal cervical cytology, 1482 (45.9%) with abnormal\ncytology. The five most common HPV types in this study were HPV16 (20.2%), HPV52 (17.1%), HPV58 (13.2%), HPV18\n(9.5%), HPV6 (7.6%). Overall, HPV16 (OR = 10.5, 95% CI: 3.7 ~ 29.6), HPV33 (OR = 9.1, 95% CI: 2.8 ~ 29.2), HPV58 (OR = 6.3,\n95% CI: 2.1 ~ 18.6), HPV31 (OR = 4.5, 95% CI: 1.3 ~ 15.5), multiple genotype infection (OR = 3.0, 95% CI: 1.7 ~ 14.7), especially\nHPV16 and HPV33, increased the risk of cytology abnormalities.\nConclusions: HPV16, HPV31, HPV33, HPV58, and multiple HPV genotype infection increased the risk of cytology\nabnormalities in Pearl River Delta Region and might be useful for the screening, preventing, treating, and monitoring of\npre-cancer lesions in southern China.
Loading....